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| The companies strategy for reducing "plastic infections" is not to bond and/or incorporate pharmaceuticals on/in the plastic, but to make the plastic, in this case silicone (PDMS) so "slippery" that bacteria to not find an anchorage ground for adhesion; they want to attach but are flushed away by micro-movements (e.g. of physiological secretions and /or the blood stream and then will be eaten up by white blood cells). The scientific basis for achieving this is i) to bond water to the surface of the silicone device (what they are routinely doing on contact lenses) and ii) to charge the surface evenly with 50% negative (-) and 50% positive (+) charges, so that any charged particle (= protein and/or bacteria) has no chance to find its counter-charge (since next door there is a repelling charge). |
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