[nanoPost] Anti-microbial nanoencapsulation

Work on biosensors in this group has involved development of polymeric membranes for solvent based dip coating onto sensor external surfaces. These membranes are variously polyurethane, PVC and cellulose acetate films that can be coated as adherent layers. They have incorporated surfactant and also low surface adhesion lipid into these polymeric films. The modified films have a range of surface polarities, and the potential to modify or reduce cell adhesion, likely to extend to microbial adhesion reduction. The incorporated agents are liquid at room temperature, so the films approximate to liquid layers.

Additionally, specific anti-microbial resistance can be incorporated, because drug release of bactericidal agent is possible.

(i) By dispersed micro/nanoparticles of low solubility bactericidal agent.

(ii) Dissolution of soluble bacteriocide into the liquid films for slow release.

(iii)  Entrapment of hollow microspheres into the films, which themselves act as drug reservoirs on the micro/nanoscale and distributed inside the films. Release rates can be varied to give steady release over extended time periods.

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