[nanoPost] Guided Drug Delivery

Company USA

The company's guided drug delivery can lead to vastly improved drug efficacy and reduced toxic side effects.  The company is developing nanomagnetic carriers designed to attach to and precisely deliver a drug to a target site and activate the drug in that area only. This can provide a high local dose with low systemic concentration and enable improved safety profiles, reduced toxic side effects, and  deliver clinical doses in excess of what is currently possible. 

This drug delivery method has a number of advantages, particularly in directing anti-cancer agents, that enable a delivery system that can overcome the limitations of existing treatments.  Most effective compounds for treating cancer are toxic and do not discriminate well which cells they attack — effecting both cancer and healthy cells. Also, some drug molecules are insoluble in aqueous media, making it difficult for them to reach their desired location in the patient.

The company’s technology, using nanomagnetic particles, overcomes these limitations by delivering anti-cancer agents directly and specifically to the targeted location. These particles could be used for magnetically guided intravenous delivery of an anti-cancer agent in the following manner:

1.  Drug is bound to nanomagnetic particles, which act as a carrier. The drug particles are attached to the surface of the nanomagnetic particle.

2.  The physician injects the nanomagnetic particles, bound to the anti-cancer drug, into the bloodstream. These nanoparticles circulate through the bloodstream.

3.  A magnetic field is applied at the target site (the tumor location, in this example) to concentrate the nanomagnetic particles in the area of interest.

4.  An electromagnetic signal is generated by the physician in the area in which the drug is desired (again, the tumor location, in this example), tuned to the nanoparticles' resonant frequency. This signal releases the drug from the nanomagnetic particles, allowing the drug to enter the target site. In addition, nanomagnetic particles can be imaged under MRI to ensure they reach their targeted destination. 

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