[nanoPost] Organ preservation

Company USA

The company is pioneering new technologies – solutions and equipment – that will enable organs for transplant to remain viable for up to three times longer than the current industry standard.

The technology is the nanoparticle component of the solution, which carries the oxygen or any type of drug or nutrient that the developers wish to place into the nanoparticle. In this case, oxygen is key to metabolism.

Key attributes of the technology solution are:

• It promotes metabolism: The proprietary solution contains both an oxygen carrier and cellular nutrients, so it acts at the cellular, not just organ level.

• It is suitable for use under varying conditions. The solution has physical and functional properties that may allow it to preserve organs over a wide range of temperature gradients. In addition, the oxygen delivery capacity of the solution is less sensitive to changes in pH, which can occur during current storage methods.

• Oxygen stability The solution has a slower rate of autoxidation and longer circulatory retention than any other known oxygen carriers.

• Less vasoactive: The solution does not cause as much vasoconstriction as some of the other known hemoglobin-based oxygen carriers. In addition, the high colloid oncotic pressure exerted by the solution may open vascular beds and reduce tissue edema. As a result, the solution may also increase the effectiveness of oxygen delivery and decrease organ morbidity during transport.

• Non-Protein Solution: The majority of oxygen-carrying solutions on the market today use animal protein as a carrier. The solution is made of synthetic materials for oxygen delivery. The scare of animal protein viruses is not an issue here.

The oxygen-carrying solution can maintain the organ or tissue's metabolic rate, not only stopping further damage from occurring, but also reversing recovery damage. This is a major advance over current technology.

The product significantly lengthens the viability of harvested organs. Our solution not only lengthens the preservation time, but also continuously nourishes the organ cells through its proprietary oxygen and nutrient carrying properties.

For example, using currently available solutions, solid organs such as kidneys and livers can be preserved without damage for twelve hours, whereas the product allows 36 hours, or a three-fold increase. The product will support the harvesting, transportation and reimplantation of kidneys, livers and hearts, as well as connective and other essential therapeutic tissues.