[nanoPost] Transport of substances and formulations across biological barriers

Company Germany

New technologies and services in research and development for the pharmaceutical, cosmetic& chemical industries. In-vitro models of cell and tissue systems form the Basis of the technology used.

They simulate the transport of substances and formulations across biological barriers, from which conclusions regarding permeability and absorption can be drawn.The customers benefit from such studies as follow:

- Substances not Suitable for development can be readily distinguished during the early phases and can at this point be side-lined. 

- Following from such a discovery, the time and financial costs experianced during the development of an active substance can be significantly lowered. 

- Cost-intensive and ethically problematic animal expts can also be reduced to a minimum.

- n-vitro models can allow the classification of formulations that can be administered via new forms, for example inhalation aerosolsor transdermal application. Additional, they allow mechanistic condusions on the in-vivo behavian of substances. 

The copanyis in a position to offer methods for classification of substances according to the BCS-guidelines of the FDA, consequently offfering the possibility of exemptions from in-vivo bio equivalence studies and in-vivo bioavailibility studies.

The use of tissue and cell cultures in the pre-clinic research consequently represents an intelligent and innovative step towards a faster, safer and less expensive development of modern active substances and formulations.