[nanoPost] Microneedles for intradermal injections and cosmetic enhancement

Company Israel

Technology Platform

- The company has developed its platform to address the need for painless, safe and efficient delivery of small and large molecules.

- The company currently develops microneedles for intradermal injections and cosmetic enhancement. 
   
 
- manufactured by MEMS (Micro Electro Mechanical Systems) technology and are made of pure silicone crystals.

- MEMS technology has enabled the creation of elaborate miniature devices with unprecedented mechanical stability and structural precision.

- The company currently develops hollow microneedles for intradermal injections and solid microprojections for cosmetic enhancement.

Vaccine dose sparing with IDD

Intradermal vaccine delivery has been repeatedly shown to allow significant dose sparing when compared to conventional administration methods such as intramuscular and subcutaneous administration. This effect is attributed to the relatively dense network of immune cells present in the skin. 
  
The company's platform offer a significant edge over current methods of IDD:

- Painless Penetration - the devices are too short to reach the pain sensing nerve endings of the skin, and are thus completely painless upon insertion.

- Non Intimidating - barely visible to the naked eye, the devices are ideal for children and needle-phobic patients.

- Minimal Performer Expertise - unlike intradermal delivery with a regular steel needle, the devices are very easy to use, and offer excellent control on delivery depth with no chance of accidental intravenous administration.

- Potential Reduced Risk for Cross Contamination - being so small, the devices potentially carry a reduced risk for contamination by used devices, offering a safer alternative for medical personnel.

- Delivery of Viscous Material - despite their miniature size, the devices mechanical properties allow easy delivery of highly viscous materials, including gelatinous substances.

Clinical data

- The company recently completed two clinical trials.

- These pilot trials were designed to test the safety and efficacy of the device as a painless needle substitute for intradermal injections. Two additional trials with the device are currently in progress with several more in set-up.

 
Preclinical data

- Numerous preclinical trials in several models, including mice, rats and pigs demonstrate that virtually any substance can be injected intradermally with the device, including extremely viscous and gelatinous substances.

- A partial list of drugs successfully administered with the device includes Insulin and other large therapeutic proteins, Lidocaine, and some thick hydrogels used in specific areas of medicine.