Research Centre Belgium Different companies are investing buckets of money in making new cosmetics including nanotechs. They are facing several problems with penetration in tissues, benefical effects on keratinocytes and dermis, photo-protection, and availability of reliable tests to assess these multiple parameters among others like anti-photoageing properties, growth of keratinocytes and dermal cells, effects of gene and protein expression. Tests on animals will be banned in the years to come and have bad press, thus bad marketing image. Tests on humans are not much easier in the first place (recruitement of volunteers to test new compounds) and are very often subjective. In vitro models are now seen as alternative. For instance reconstructed epidermis has been identified as a solution. Until now these reconstructed epidermes were troublesome as concerns reproducibility of the tests due to the human donor's age, sex, ethical agreements for consent, etc. We have just developed a new system which bypasses all these problems. We could disclose this system after signature of a confidentiality agreement. We believe this system could be used for testing all the parameters listed above since we provide in vitro system with much better reproducibility, and are able to assess all the parameters described above (patent pending). We could also put you in touch with a network of a few labs interested in these systems as concerns nanoparticles in cosmetics. We could develop these systems thanks to a remarkable expertise in cell stress. |
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